SDCBP

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017]

Syndecan Binding Protein

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527).
Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292).
In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413).
Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120).
In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591).
May also play a role in vesicular trafficking (PubMed:11179419).
Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).

Biological Process actin cytoskeleton organization1 PublicationNAS:UniProtKB
Biological Process chemical synaptic transmission1 PublicationNAS:UniProtKB
Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of receptor internalizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of extracellular exosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of JNK cascade1 PublicationIC:BHF-UCL
Biological Process positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process presynapse assemblyIEA:Ensembl
Biological Process protein targeting to membrane1 PublicationNAS:UniProtKB
Biological Process Ras protein signal transductionIEA:Ensembl
Biological Process regulation of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process substrate-dependent cell migration, cell extension1 PublicationNAS:UniProtKB

Cell junction, focal adhesion
Cell junction, adherens junction
Cell membrane 3 Publications; Peripheral membrane protein
Endoplasmic reticulum membrane
Nucleus
Melanosome
Cytoplasm, cytosol
Cytoplasm, cytoskeleton
Secreted, extracellular exosome
Membrane raft
Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966).

Phosphorylated on tyrosine residues.