SELP

This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]

Full Name

Selectin P

Function

Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.

Biological Process

Biological Process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process calcium-mediated signaling using intracellular calcium sourceManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process defense response to Gram-negative bacterium1 PublicationIC:BHF-UCL
Biological Process heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inflammatory responseIEA:Ensembl
Biological Process leukocyte cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of leukocyte migrationIEA:Ensembl
Biological Process positive regulation of leukocyte tethering or rollingISS:UniProtKB
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of platelet activationBy SimilarityISS:BHF-UCL
Biological Process regulation of integrin activationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to cytokineManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to lipopolysaccharide1 PublicationIC:BHF-UCL

Cellular Location

Cell membrane

Involvement in disease

Ischemic stroke (ISCHSTR):
A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

Topology

Extracellular: 42-771
Helical: 772-795
Cytoplasmic: 796-830

SELP

Anti-SELP antibodies