SEPT1

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]

Septin 1

Filament-forming cytoskeletal GTPase (By similarity).
May play a role in cytokinesis (Potential).

Biological Process cytoskeleton-dependent cytokinesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein localizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm
Cytoplasm, cytoskeleton
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Midbody
Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis.