SGF29

CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

Full Name

SGF29

Function

Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293).
SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293).
In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016).
Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).
Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity).

Biological Process

Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process establishment of protein localization to chromatinManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process histone acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process histone H3 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process histone H3-K14 acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process monoubiquitinated histone deubiquitinationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process monoubiquitinated histone H2A deubiquitinationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process positive regulation of DNA-templated transcription1 PublicationIC:ComplexPortal
Biological Process regulation of cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of cell divisionManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of DNA repair1 PublicationIC:ComplexPortal
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of embryonic developmentIC:ComplexPortal
Biological Process regulation of histone deacetylationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of RNA splicing1 PublicationIC:ComplexPortal
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of tubulin deacetylationManual Assertion Based On ExperimentIMP:ComplexPortal

Cellular Location

Nucleus