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Mouse Anti-SGF29 Recombinant Antibody (CBXC-1758) (CBMAB-C5592-CQ)

This product is a mouse antibody that recognizes SGF29. The antibody CBXC-1758 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SGF29 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1758
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SGF29
Introduction
CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]
Entrez Gene ID
112869
UniProt ID
Q96ES7
Alternative Names
SAGA Complex Associated Factor 29; Coiled-Coil Domain-Containing Protein 101; Coiled-Coil Domain Containing 101; CCDC101; SAGA-Associated Factor 29 Homolog (Yeast); SAGA-Associated Factor 29 Homolog;
Function
Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293).
SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293).
In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016).
Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).
Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity).
Biological Process
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process establishment of protein localization to chromatinManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process histone acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process histone H3 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process histone H3-K14 acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process monoubiquitinated histone deubiquitinationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process monoubiquitinated histone H2A deubiquitinationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process positive regulation of DNA-templated transcription1 PublicationIC:ComplexPortal
Biological Process regulation of cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of cell divisionManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of DNA repair1 PublicationIC:ComplexPortal
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of embryonic developmentIC:ComplexPortal
Biological Process regulation of histone deacetylationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of RNA splicing1 PublicationIC:ComplexPortal
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of tubulin deacetylationManual Assertion Based On ExperimentIMP:ComplexPortal
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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