SLC24A2

This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Full Name

Solute Carrier Family 24 Member 2

Function

Calcium, potassium:sodium antiporter that transports 1 Ca2+ and 1 K+ in exchange for 4 Na+ (PubMed:10662833, PubMed:26631410).
Required for learming and memory by regulating neuronal Ca2+, which is essential for the development of synaptic plasticity (By similarity).

Biological Process

Biological Process calcium ion importManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process calcium ion import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process calcium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process cellular response to high light intensityISS:ARUK-UCL
Biological Process cone photoresponse recoveryISS:ARUK-UCL
Biological Process ion transmembrane transportManual Assertion Based On ExperimentIDA:MGI
Biological Process ion transportTAS:Reactome
Biological Process long-term synaptic depressionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process long-term synaptic potentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process phototransductionISS:ARUK-UCL
Biological Process potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process visual perceptionIEA:InterPro

Cellular Location

Cell membrane