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Mouse Anti-SLC24A2 Recombinant Antibody (F-2) (CBMAB-N4277-WJ)

This product is a Mouse antibody that recognizes SLC24A2. The antibody F-2 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SLC24A2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
F-2
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 24 Member 2
Introduction
This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Entrez Gene ID
Human25769
Mouse76376
Rat84550
UniProt ID
HumanQ9UI40
MouseQ8BUN9
RatO54701
Alternative Names
Solute Carrier Family 24 Member 2; Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 2; Na(+)/K(+)/Ca(2+)-Exchange Protein 2; Retinal Cone Na-Ca+K Exchanger; NCKX2; Sodium/Potassium/Calcium Exchanger 2;
Function
Calcium, potassium:sodium antiporter that transports 1 Ca2+ and 1 K+ in exchange for 4 Na+ (PubMed:10662833, PubMed:26631410).
Required for learming and memory by regulating neuronal Ca2+, which is essential for the development of synaptic plasticity (By similarity).
Biological Process
Biological Process calcium ion importManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process calcium ion import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process calcium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process cellular response to high light intensityISS:ARUK-UCL
Biological Process cone photoresponse recoveryISS:ARUK-UCL
Biological Process ion transmembrane transportManual Assertion Based On ExperimentIDA:MGI
Biological Process ion transportTAS:Reactome
Biological Process long-term synaptic depressionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process long-term synaptic potentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process phototransductionISS:ARUK-UCL
Biological Process potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process visual perceptionIEA:InterPro
Cellular Location
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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