SLC29A1

SLC29A1 is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies.

Full Name

Solute Carrier Family 29 Member 1 (Augustine Blood Group)

Function

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).

Biological Process

Biological Process adenosine transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process cellular response to glucose stimulusIEA:Ensembl
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process excitatory postsynaptic potentialIEA:Ensembl
Biological Process lactationIEA:Ensembl
Biological Process neurotransmitter reuptakeManual Assertion Based On ExperimentIMP:SynGO
Biological Process neurotransmitter transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process neurotransmitter uptakeISS:ARUK-UCL
Biological Process nucleobase-containing compound metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process nucleoside transmembrane transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process nucleoside transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process purine nucleoside transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process pyrimidine-containing compound transmembrane transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process sleepIEA:Ensembl
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Biological Process uridine transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process xenobiotic transmembrane transportTAS:Reactome

Cellular Location

Basolateral cell membrane
Apical cell membrane
Cell membrane
Predominantly localized in the basolateral membrane in polarized MDCK cells.

PTM

Glycosylated.