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Rabbit Anti-SLC29A1 Recombinant Antibody (CBFYE-1651) (CBMAB-E2319-FY)

This product is rabbit antibody that recognizes SLC29A1. The antibody CBFYE-1651 can be used for immunoassay techniques such as: IHC-P.
See all SLC29A1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYE-1651
Antibody Isotype
IgG
Application
IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 29 Member 1 (Augustine Blood Group)
Introduction
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
Entrez Gene ID
2030
UniProt ID
Q99808
Alternative Names
Solute Carrier Family 29 Member 1 (Augustine Blood Group); Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member 1; Nucleoside Transporter, Es-Type; ENT1; Equilibrative Nitrobenzylmercaptopurine Riboside (NBMPR)-Sensitive Nucleoside Transporter; Equilibrative Nitrobenzylmercaptopurine Riboside-Sensitive Nucleoside Transporter
Function
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
Biological Process
Biological Process adenosine transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process cellular response to glucose stimulusIEA:Ensembl
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process excitatory postsynaptic potentialIEA:Ensembl
Biological Process lactationIEA:Ensembl
Biological Process neurotransmitter reuptakeManual Assertion Based On ExperimentIMP:SynGO
Biological Process neurotransmitter transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process neurotransmitter uptakeISS:ARUK-UCL
Biological Process nucleobase-containing compound metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process nucleoside transmembrane transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process nucleoside transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process purine nucleoside transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process pyrimidine-containing compound transmembrane transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process sleepIEA:Ensembl
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Biological Process uridine transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process xenobiotic transmembrane transportTAS:Reactome
Cellular Location
Basolateral cell membrane
Apical cell membrane
Cell membrane
Predominantly localized in the basolateral membrane in polarized MDCK cells.
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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