SLC2A2

This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene.
Full Name
solute carrier family 2 member 2
Function
Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:8027028, PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8457197).
Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028).
May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500).
Also able to mediate the transport of dehydroascorbate (PubMed:23396969).
Biological Process
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dehydroascorbic acid transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process fructose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process galactose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glucose importManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glucose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process monosaccharide transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Involvement in disease
Fanconi-Bickel syndrome (FBS):
Rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.
PTM
N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.
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Anti-SLC2A2 antibodies

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Recombinant Rabbit Anti-SLC2A2 Antibody (CBAb221) (CBMAB-Ab221-LY)

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Target: SLC2A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb221
Application*: WB
Datasheet SDS

Rat Anti-SLC2A2 (Extracellular Domain) Recombinant Antibody (CBXS-0452) (CBMAB-S3402-CQ)

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Target: SLC2A2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXS-0452
Application*: F, WB
Datasheet SDS

Mouse Anti-SLC2A2 Recombinant Antibody (CBXS-0451) (CBMAB-S3401-CQ)

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Target: SLC2A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-0451
Application*: F, IC, P
Datasheet SDS

Mouse Anti-SLC2A2 Recombinant Antibody (CBXS-0450) (CBMAB-S3400-CQ)

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Target: SLC2A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-0450
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-SLC2A2 Recombinant Antibody (CBXS-0449) (CBMAB-S3399-CQ)

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Target: SLC2A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-0449
Application*: P
Datasheet SDS

Mouse Anti-SLC2A2 Recombinant Antibody (CBXS-3781) (CBMAB-S1053-CQ)

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Target: SLC2A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3781
Application*: F, IH
Datasheet SDS

Rat Anti-SLC2A2 Recombinant Antibody (CBFYH-3347) (CBMAB-H0410-FY)

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Target: SLC2A2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYH-3347
Application*: F
Datasheet SDS

Mouse Anti-SLC2A2 Recombinant Antibody (CBLG1-2437) (CBMAB-G6566-LY)

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Target: SLC2A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2437
Application*: F
Datasheet SDS

Mouse Anti-SLC2A2 Recombinant Antibody (5D1) (CBMAB-G6563-LY)

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Target: SLC2A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5D1
Application*: WB
Datasheet SDS

Rat Anti-SLC2A2 Recombinant Antibody (11C102) (CBMAB-G6562-LY)

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Target: SLC2A2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 11C102
Application*: WB
Datasheet SDS

Rat Anti-SLC2A2 Recombinant Antibody (205115) (CBMAB-G1180-LY)

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Target: SLC2A2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 205115
Application*: F
Datasheet SDS

Mouse Anti-SLC2A2 Recombinant Antibody (199017) (CBMAB-G1179-LY)

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Target: SLC2A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 199017
Application*: F
Datasheet SDS

Mouse Anti-SLC2A2 Recombinant Antibody (CBFYH-2762) (CBMAB-H0372-FY)

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Target: SLC2A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2762
Application*: F
Datasheet SDS

Rabbit Anti-SLC2A2 Recombinant Antibody (
37E1) (V2LY-0725-LY1209)

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Target: SLC2A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 37E1
Application*: E, IH, IF, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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