SLC2A5

The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption.
Full Name
Solute Carrier Family 2 Member 5
Function
Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543, PubMed:16186102, PubMed:28083649, PubMed:17710649, PubMed:29548810).
Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905).
Essential for fructose uptake in the small intestine (By similarity).
Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity).
Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).
Biological Process
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to fructose stimulusISS:UniProtKB
Biological Process fructose import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process fructose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glucose transmembrane transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process intestinal hexose absorptionTAS:Reactome
Biological Process monosaccharide transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of systemic arterial blood pressure mediated by a chemical signalISS:UniProtKB
Biological Process response to fructoseISS:UniProtKB
Cellular Location
Apical cell membrane
Cell membrane
Cell membrane, sarcolemma
Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A.
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Anti-SLC2A5 antibodies

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Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-4440) (CBMAB-S1682-CQ)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4440
Application*: P, IP, WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-4259) (CBMAB-S1510-CQ)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4259
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-3725) (CBMAB-S1000-CQ)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXS-3725
Application*: IC, IF, IH, WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-3704) (CBMAB-S0979-CQ)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3704
Application*: IF, WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-3690) (CBMAB-S0965-CQ)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3690
Application*: F, IF, IP, WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-3654) (CBMAB-S0933-CQ)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3654
Application*: P, IP, WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-5981) (CBMAB-S0828-CQ)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5981
Application*: IP, WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-5974) (CBMAB-S0821-CQ)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5974
Application*: P, WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (9H4) (CBMAB-G6588-LY)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 9H4
Application*: WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (9G8) (CBMAB-G6587-LY)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9G8
Application*: IC/IF, IH, P, WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (9F3) (CBMAB-G6586-LY)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 9F3
Application*: WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (2C4) (CBMAB-G6585-LY)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C4
Application*: IH, P, IP, WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (20E1) (CBMAB-G6584-LY)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 20E1
Application*: F
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (14C8) (CBMAB-G6583-LY)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14C8
Application*: F
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (13A10) (CBMAB-G6582-LY)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13A10
Application*: WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (12F2) (CBMAB-G6581-LY)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12F2
Application*: WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (11E1) (CBMAB-G6580-LY)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11E1
Application*: IC/IF, WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (11D11) (CBMAB-G6579-LY)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11D11
Application*: IH, P, IP, WB
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (11C105) (CBMAB-G6578-LY)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 11C105
Application*: F
Datasheet SDS

Mouse Anti-SLC2A5 Recombinant Antibody (195205) (CBMAB-G1187-LY)

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Target: SLC2A5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 195205
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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