Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-3654) (CBMAB-S0933-CQ)

Name: Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-3654)
SKU: CBMAB-S0933-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBXS-3654

Application

IHC-P, IP, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Solute Carrier Family 2 Member 5

Introduction

The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption.

Entrez Gene ID

6518

UniProt ID

P22732

Alternative Names

Solute Carrier Family 2 Member 5; Solute Carrier Family 2 (Facilitated Glucose/Fructose Transporter), Member 5; Glucose Transporter Type 5, Small Intestine; GLUT-5; GLUT5; Solute Carrier Family 2, Facilitated Glucose Transporter Member 5; Glucose Transporter-Like Protein 5; Testicular Tissue Protein Li 81; Fructose Transporter;

Function

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543, PubMed:16186102, PubMed:28083649, PubMed:17710649, PubMed:29548810).
Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905).
Essential for fructose uptake in the small intestine (By similarity).
Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity).
Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).

Biological Process

Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to fructose stimulusISS:UniProtKB
Biological Process fructose import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process fructose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glucose transmembrane transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process intestinal hexose absorptionTAS:Reactome
Biological Process monosaccharide transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of systemic arterial blood pressure mediated by a chemical signalISS:UniProtKB
Biological Process response to fructoseISS:UniProtKB

Cellular Location

Apical cell membrane
Cell membrane
Cell membrane, sarcolemma
Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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