SLIT1

Slit homolog 1 protein is a protein that in humans is encoded by the SLIT1 gene.

Full Name

Slit Guidance Ligand 1

Function

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity).
SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.

Biological Process

Biological Process axon extension involved in axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process dorsal/ventral axon guidanceIEA:Ensembl
Biological Process forebrain morphogenesis1 PublicationNAS:UniProtKB
Biological Process motor neuron axon guidanceManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of axon extension involved in axon guidanceIEA:Ensembl
Biological Process negative regulation of synapse assemblyISS:UniProtKB
Biological Process nuclear migrationIEA:Ensembl
Biological Process retinal ganglion cell axon guidanceIEA:Ensembl
Biological Process spinal cord developmentIEA:Ensembl
Biological Process tangential migration from the subventricular zone to the olfactory bulbIEA:Ensembl

Cellular Location

Secreted