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SNCG

This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]
Full Name
Synuclein Gamma
Function
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity).
May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
Biological Process
Biological Process adult locomotory behaviorIEA:Ensembl
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein secretionIEA:Ensembl
Biological Process regulation of dopamine secretionIEA:Ensembl
Biological Process regulation of neuron deathManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of neurotransmitter secretionIEA:Ensembl
Biological Process synapse organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synaptic vesicle endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
PTM
Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.

Anti-SNCG antibodies

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Target: SNCG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 514304
Application*: WB
Target: SNCG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2441
Application*: WB
Target: SNCG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4206
Application*: E, IH, WB
Target: SNCG
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4435
Application*: E, WB
Target: SNCG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5486
Application*: E, IH
Target: SNCG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0610
Application*: E, C, P, WB
Target: SNCG
Host: Mouse
Specificity: Human
Clone: CBXS-0611
Application*: WB, IC, P, C, E
Target: SNCG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1H10D2
Application*: E, IH, P, WB
Target: SNCG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLNG-182
Application*: WB, IC, IH
Target: SNCG
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 11BA33
Application*: E, WB
Target: SNCG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 11BA34
Application*: E, WB
Target: SNCG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 11BA35
Application*: WB
Target: SNCG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBXS-3527
Application*: F, IC, IH, IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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