SPAG9

This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Full Name

Sperm Associated Antigen 9

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216).
Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937).
Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity).

Biological Process

Biological Process lysosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of dendrite extensionIEA:Ensembl
Biological Process negative regulation of neuron differentiationIEA:Ensembl
Biological Process negative regulation of protein phosphorylationIEA:Ensembl
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of neuron differentiationIEA:Ensembl
Biological Process retrograde transport, endosome to GolgiManual Assertion Based On ExperimentIDA:MGI
Biological Process striated muscle cell differentiationIEA:Ensembl
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Cytoplasm, perinuclear region
Lysosome membrane
Perinuclear distribution in response to stress signals such as UV radiation.
Isoform 5
Cytoplasmic vesicle, secretory vesicle, acrosome
Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.

PTM

Phosphorylated by MAPK8 and MAPK14.