Rabbit Anti-SPAG9 Recombinant Antibody (D72F4) (CBMAB-0321-WJ)

Name: Rabbit Anti-SPAG9 Recombinant Antibody (D72F4)
SKU: CBMAB-0321-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

D72F4

Application

WB, IP, IHC-P, IF, FC

Specificity

Human, Mouse, Rat, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Sperm Associated Antigen 9

Introduction

This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. Diseases associated with SPAG9 include Cardiomyopathy, Familial Hypertrophic, 2 and Hodgkin's Lymphoma, Mixed Cellularity. Among its related pathways are Akt Signaling and Myogenesis. An important paralog of this gene is MAPK8IP3.

Entrez Gene ID

Human	9043
Mouse	70834
Rat	360600
Monkey	707613

UniProt ID

Human	O60271
Mouse	Q58A65
Rat	E9PSJ4
Monkey	F6YGF0

Alternative Names

SPAG9; sperm associated antigen 9; C-Jun-amino-terminal kinase-interacting protein 4; c Jun NH2 terminal kinase associated leucine zipper protein; cancer/testis antigen 89; CT89; FLJ13450; FLJ14006; FLJ26141; FLJ34602; HLC 4 protein; HLC4; HSS; JLP; JNK interacting protein; JNK associated leucine zipper protein; JNK/SAPK associated protein; KIAA0516; lung cancer oncogene 4; Max binding protein; MGC14967; MGC74461; MGC117291; PHET; PIG6; proliferation inducing gene 6; sperm specific protein; sperm surface protein; SYD1; sunday driver 1; Max-binding protein; JNK/SAPK-associated protein; proliferation-inducing gene 6; protein highly expressed in testis; human lung cancer oncogene 6 protein; mitogen-activated protein kinase 8-interacting protein 4; c-Jun NH2-terminal kinase-associated leucine zipper protein; HLC6; JIP4; HLC-6; JIP-4

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216).
Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937).
Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity).

Biological Process

Biological Process lysosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of dendrite extensionIEA:Ensembl
Biological Process negative regulation of neuron differentiationIEA:Ensembl
Biological Process negative regulation of protein phosphorylationIEA:Ensembl
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of neuron differentiationIEA:Ensembl
Biological Process retrograde transport, endosome to GolgiManual Assertion Based On ExperimentIDA:MGI
Biological Process striated muscle cell differentiationIEA:Ensembl
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Cytoplasm, perinuclear region
Lysosome membrane
Perinuclear distribution in response to stress signals such as UV radiation.
Isoform 5
Cytoplasmic vesicle, secretory vesicle, acrosome
Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.

PTM

Phosphorylated by MAPK8 and MAPK14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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