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SSX1

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. [provided by RefSeq]
Full Name
synovial sarcoma, X breakpoint 1
Function
Could act as a modulator of transcription.
Biological Process
Negative regulation of transcription by RNA polymerase II
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
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Anti-SSX1 antibodies

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Mouse Anti-SSX1 Recombinant Antibody (5B2) (CBMAB-A8618-LY)

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Target: SSX1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5B2
Application*: WB, E
Datasheet SDS

Mouse Anti-SSX1 Recombinant Antibody (CBXS-2118) (CBMAB-S4883-CQ)

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Target: SSX1
Host: Mouse
Specificity: Human
Clone: CBXS-2118
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SSX1 Recombinant Antibody (CBXS-2114) (CBMAB-S4879-CQ)

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Target: SSX1
Host: Mouse
Specificity: Human
Clone: CBXS-2114
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SSX1 Recombinant Antibody (CBXS-4627) (CBMAB-S1867-CQ)

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Target: SSX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4627
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SSX1 Recombinant Antibody (CBXS-4606) (CBMAB-S1846-CQ)

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Target: SSX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4606
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-SSX1 Recombinant Antibody (CBXS-4561) (CBMAB-S1801-CQ)

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Target: SSX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4561
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SSX1 Recombinant Antibody (CBXS-4481) (CBMAB-S1723-CQ)

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Target: SSX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4481
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SSX1 Recombinant Antibody (CBXS-4035) (CBMAB-S1296-CQ)

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Target: SSX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4035
Application*: WB, F, IH, IF, P
Datasheet SDS

Mouse Anti-SSX1 Recombinant Antibody (CBXS-3960) (CBMAB-S1223-CQ)

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Target: SSX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3960
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SSX1 Recombinant Antibody (CBXS-3880) (CBMAB-S1149-CQ)

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Target: SSX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3880
Application*: F, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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