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Mouse Anti-SSX1 Recombinant Antibody (CBXS-3880) (CBMAB-S1149-CQ)

This product is a mouse antibody that recognizes SSX1. The antibody CBXS-3880 can be used for immunoassay techniques such as: FC, IF, WB.
See all SSX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3880
Antibody Isotype
IgG1
Application
FC, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
synovial sarcoma, X breakpoint 1
Introduction
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X.
Entrez Gene ID
6756
UniProt ID
Q16384
Alternative Names
SSX Family Member 1; Synovial Sarcoma, X Breakpoint 1; Cancer/Testis Antigen Family 5, Member 1; Cancer/Testis Antigen 5.1; CT5.1; Sarcoma, Synovial, X-Chromosome-Related 1; Protein SSX1; SSRC;
Function
Could act as a modulator of transcription.
Biological Process
Negative regulation of transcription by RNA polymerase II
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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