ST8SIA4

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.

Biological Process ganglioside biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process N-glycan processingManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process oligosaccharide metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein glycosylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein modification processManual Assertion Based On ExperimentTAS:ProtInc

Golgi apparatus membrane

Cytoplasmic: 1-7
Helical: 8-20
Lumenal: 21-359