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Mouse Anti-ST8SIA4 Recombinant Antibody (CBXS-4223) (CBMAB-S1475-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4223
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Introduction
The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
7903
UniProt ID
Q92187
Alternative Names
PST; PST1; SIAT8D; ST8SIA-IV
Function
Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.
Biological Process
Biological Process ganglioside biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process N-glycan processingManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process oligosaccharide metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein glycosylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein modification processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-7
Helical: 8-20
Lumenal: 21-359
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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