STK39

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.

Serine/threonine kinase 39

May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.

Biological Process cellular chloride ion homeostasisIEA:Ensembl
Biological Process cellular hypotonic response1 PublicationIC:ParkinsonsUK-UCL
Biological Process cellular response to chemokineManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cellular response to potassium ionIEA:Ensembl
Biological Process chemokine (C-X-C motif) ligand 12 signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process inflammatory responseIEA:Ensembl
Biological Process intracellular signal transductionManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process macrophage activationIEA:Ensembl
Biological Process maintenance of lens transparencyISS:ParkinsonsUK-UCL
Biological Process negative regulation of creatine transmembrane transporter activityManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process negative regulation of pancreatic juice secretionIEA:Ensembl
Biological Process negative regulation of potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process negative regulation of potassium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process negative regulation of sodium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process peptidyl-threonine phosphorylationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process positive regulation of ion transmembrane transporter activityISS:ParkinsonsUK-UCL
Biological Process positive regulation of p38MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of potassium ion transportIEA:Ensembl
Biological Process positive regulation of T cell chemotaxisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein phosphorylationISS:UniProtKB
Biological Process regulation of blood pressureIEA:Ensembl
Biological Process regulation of inflammatory responseIEA:Ensembl
Biological Process response to aldosteroneIEA:Ensembl
Biological Process response to dietary excessIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process sodium ion transmembrane transportIEA:Ensembl

Cytoplasm
Nucleus
Nucleus when caspase-cleaved.

Phosphorylated at Ser-309 by PRKCQ (PubMed:14988727).
Autophosphorylation at Thr-231 positively regulates its activity (By similarity).