Human Recombinant STK39, Active protein, His Tag (V2LY-0526-LY7002)

Serine/threonine kinase 39

May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.

Biological Process cellular chloride ion homeostasisIEA:Ensembl
Biological Process cellular hypotonic response1 PublicationIC:ParkinsonsUK-UCL
Biological Process cellular response to chemokineManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cellular response to potassium ionIEA:Ensembl
Biological Process chemokine (C-X-C motif) ligand 12 signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process inflammatory responseIEA:Ensembl
Biological Process intracellular signal transductionManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process macrophage activationIEA:Ensembl
Biological Process maintenance of lens transparencyISS:ParkinsonsUK-UCL
Biological Process negative regulation of creatine transmembrane transporter activityManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process negative regulation of pancreatic juice secretionIEA:Ensembl
Biological Process negative regulation of potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process negative regulation of potassium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process negative regulation of sodium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process peptidyl-threonine phosphorylationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process positive regulation of ion transmembrane transporter activityISS:ParkinsonsUK-UCL
Biological Process positive regulation of p38MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of potassium ion transportIEA:Ensembl
Biological Process positive regulation of T cell chemotaxisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein phosphorylationISS:UniProtKB
Biological Process regulation of blood pressureIEA:Ensembl
Biological Process regulation of inflammatory responseIEA:Ensembl
Biological Process response to aldosteroneIEA:Ensembl
Biological Process response to dietary excessIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process sodium ion transmembrane transportIEA:Ensembl

Cytoplasm
Nucleus
Nucleus when caspase-cleaved.

Phosphorylated at Ser-309 by PRKCQ (PubMed:14988727).
Autophosphorylation at Thr-231 positively regulates its activity (By similarity).