SYNGR1

This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified.

Full Name

Synaptogyrin 1

Function

May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity).
Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).

Biological Process

Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process protein targetingIEA:Ensembl
Biological Process regulated exocytosisISS:UniProtKB
Biological Process regulation of long-term neuronal synaptic plasticityISS:UniProtKB
Biological Process regulation of short-term neuronal synaptic plasticityISS:UniProtKB
Biological Process synaptic vesicle membrane organizationISS:UniProtKB

Cellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Topology

Cytoplasmic: 1-23
Helical: 24-44
Lumenal: 45-71
Helical: 72-92
Cytoplasmic: 93-103
Helical: 104-124
Lumenal: 125-148
Helical: 149-169
Cytoplasmic: 170-233