SYT5

Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).

Full Name

synaptotagmin V

Function

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca2+-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).

Biological Process

Biological Process calcium ion-regulated exocytosis of neurotransmitterIBA:GO_Central1 Publication
Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process chemical synaptic transmissionTAS:ProtInc1 Publication
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process synaptic vesicle endocytosisIBA:GO_Central1 Publication
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication

Cellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Recycling endosome membrane
In mast cells, localizes to the endocytic recycling compartment.

Topology

Vesicular: 1-24
Helical: 25-45
Cytoplasmic: 46-386