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Mouse Anti-SYT5 Recombinant Antibody (CBXS-2228) (CBMAB-S4990-CQ)

This product is a mouse antibody that recognizes SYT5. The antibody CBXS-2228 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SYT5 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
CBXS-2228
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
synaptotagmin V
Introduction
Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).
Entrez Gene ID
Mouse53420
Rat54309
UniProt ID
MouseQ9R0N5
RatP47861
Alternative Names
SytV
Function
May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca2+-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).
Biological Process
Biological Process calcium ion-regulated exocytosis of neurotransmitterIBA:GO_Central1 Publication
Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process chemical synaptic transmissionTAS:ProtInc1 Publication
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process synaptic vesicle endocytosisIBA:GO_Central1 Publication
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Recycling endosome membrane
In mast cells, localizes to the endocytic recycling compartment.
Topology
Vesicular: 1-24
Helical: 25-45
Cytoplasmic: 46-386
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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