TACC1

TACC1 may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for TACC1.

Full Name

Transforming Acidic Coiled-Coil Containing Protein 1

Function

Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863).
Might promote the nuclear localization of the receptors (PubMed:20078863).
Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

Biological Process

Biological Process cell divisionIEA:UniProtKB-KW
Biological Process cell population proliferationIBA:GO_Central1 Publication
Biological Process cerebral cortex developmentIBA:GO_Central1 Publication
Biological Process microtubule cytoskeleton organizationIBA:GO_Central1 Publication
Biological Process mitotic spindle organizationIEA:InterPro

PTM

Isoform 1 is heavily phosphorylated; isoform 6 is not.

Anti-TACC1 antibodies

Mouse Anti-TACC1 Recombinant Antibody (CBYJT-1767) (CBMAB-T0828-YJ)

Datasheet

SDS

Target: TACC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-1767

Application*: WB, IH

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)