TACC1

TACC1 may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for TACC1.

Full Name

Transforming Acidic Coiled-Coil Containing Protein 1

Function

Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863).
Might promote the nuclear localization of the receptors (PubMed:20078863).
Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

Biological Process

Biological Process cell divisionIEA:UniProtKB-KW
Biological Process cell population proliferationIBA:GO_Central1 Publication
Biological Process cerebral cortex developmentIBA:GO_Central1 Publication
Biological Process microtubule cytoskeleton organizationIBA:GO_Central1 Publication
Biological Process mitotic spindle organizationIEA:InterPro

PTM

Isoform 1 is heavily phosphorylated; isoform 6 is not.