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TAF1C

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified. [provided by RefSeq]

Full Name

TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa

Function

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.

Biological Process

Biological Process transcription by RNA polymerase ITAS:ProtInc1 Publication
Biological Process transcription by RNA polymerase IITAS:ProtInc1 Publication
Biological Process transcription initiation at RNA polymerase I promoterNAS:ParkinsonsUK-UCL1 Publication

Cellular Location

Nucleus

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Anti-TAF1C antibodies

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Mouse Anti-TAF1C Recombinant Antibody (CBYJT-1861) (CBMAB-T0929-YJ)

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Target: TAF1C

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-1861

Application*: WB, E

Mouse Anti-TAF1C Recombinant Antibody (CBYJT-1860) (CBMAB-T0928-YJ)

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Target: TAF1C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1860

Application*: WB, IP, IF, E

Mouse Anti-TAF1C Recombinant Antibody (CBYJT-1859) (CBMAB-T0927-YJ)

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Target: TAF1C

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-1859

Application*: E, WB

Rabbit Anti-TAF1C Recombinant Antibody (CBYJT-1858) (CBMAB-T0926-YJ)

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Target: TAF1C

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1858

Application*: WB, IP

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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