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Mouse Anti-TAF1C Recombinant Antibody (CBYJT-1859) (CBMAB-T0927-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAF1C (TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit C). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TAF1C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1859
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa761-870 from TAF1C (NP_005670) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 761-870

Target

Full Name
TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
Introduction
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. TAF1C is the largest SL1-specific TAF.
Entrez Gene ID
UniProt ID
Alternative Names
TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit C; TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, C, 110kDa; TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, C, 110kD; RNA Polymerase I-Specific TBP-Associated Factor 110 KDa; Transcription Initiation Factor SL1/TIF-IB Subunit C; TATA Box-Binding Protein-Associated Factor 1C; TBP-Associated Factor 1C; TAFI110
Function
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.
Biological Process
Biological Process transcription by RNA polymerase ITAS:ProtInc1 Publication
Biological Process transcription by RNA polymerase IITAS:ProtInc1 Publication
Biological Process transcription initiation at RNA polymerase I promoterNAS:ParkinsonsUK-UCL1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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