TANC2

TANC2 (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 2) is a Protein Coding gene. Diseases related to TANC2 include Oral Hairy Leukoplakia. An important paralog of TANC2 is TANC1.

Full Name

Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 2

Function

Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines.

Biological Process

Biological Process dense core granule cytoskeletal transportISS:UniProtKB
Biological Process regulation of dendritic spine developmentISS:UniProtKB
Biological Process regulation of dendritic spine morphogenesisISS:UniProtKB

Cellular Location

Cell projection, dendritic spine

Involvement in disease

Intellectual developmental disorder with autistic features and language delay, with or without seizures (IDDALDS):
An autosomal dominant neurodevelopmental disorder characterized by global developmental delay, varying degrees of intellectual disability, autism spectrum disorder, and delayed language. Some patients develop seizures.