TBC1D21

TBC1D21 may act as a GTPase-activating protein for Rab family protein(s) (PubMed:19077034). TBC1D21 may be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978).

TBC1 Domain Family Member 21

Acts as a GTPase-activating protein for Rab family protein(s) (PubMed:28067790, PubMed:19077034).
Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function (By similarity).
Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail (By similarity).
Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3 (By similarity).
May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978).

Biological Process activation of GTPase activityIBA:GO_Central1 Publication
Biological Process flagellated sperm motilityISS:UniProtKB
Biological Process sperm axoneme assemblyISS:UniProtKB
Biological Process sperm mitochondrial sheath assemblyISS:UniProtKB
Biological Process spermatogenesisISS:UniProtKB

Cytoplasmic vesicle, secretory vesicle, acrosome
Cytoplasm, cytoskeleton
Located at the edge of the acrosomal region, neck and annulus during spermiogenesis. Colocalizes with RAB3A at the acrosome-acroplaxome and neck regions of spermatids. Colocalizes with ACTB at the neck region in elongated spermatids.