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Mouse Anti-TBC1D21 Recombinant Antibody (CBYJT-2040) (CBMAB-T1135-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBC1D21 (TBC1 Domain Family Member 21). The antibody can be used for immunoassay techniques, such as WB, IHC.
See all TBC1D21 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2040
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human TBC1D21(NP_699187) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TBC1 Domain Family Member 21
Introduction
TBC1D21 may act as a GTPase-activating protein for Rab family protein(s) (PubMed:19077034). TBC1D21 may be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978).
Entrez Gene ID
161514
UniProt ID
Q8IYX1
Alternative Names
MgcRabGAP
Function
Acts as a GTPase-activating protein for Rab family protein(s) (PubMed:28067790, PubMed:19077034).
Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function (By similarity).
Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail (By similarity).
Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3 (By similarity).
May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978).
Biological Process
Biological Process activation of GTPase activityIBA:GO_Central1 Publication
Biological Process flagellated sperm motilityISS:UniProtKB
Biological Process sperm axoneme assemblyISS:UniProtKB
Biological Process sperm mitochondrial sheath assemblyISS:UniProtKB
Biological Process spermatogenesisISS:UniProtKB
Cellular Location
Cytoplasmic vesicle, secretory vesicle, acrosome
Cytoplasm, cytoskeleton
Located at the edge of the acrosomal region, neck and annulus during spermiogenesis. Colocalizes with RAB3A at the acrosome-acroplaxome and neck regions of spermatids. Colocalizes with ACTB at the neck region in elongated spermatids.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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