TCERG1

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TCERG1 Gene(Protein Coding)


Transcription Elongation Regulator 1

Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.

Biological Process mRNA processingIDA:ARUK-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process negative regulation of transcription elongation by RNA polymerase IITAS:ARUK-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:ARUK-UCL1 Publication
Biological Process positive regulation of transcription elongation by RNA polymerase IITAS:ARUK-UCL1 Publication
Biological Process RNA splicingIDA:ARUK-UCL1 Publication

Nucleus