THBS2
THBS2 belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. It has been shown to play a role as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.
Full Name
Thrombospondin 2
Function
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
Biological Process
Biological Process cell adhesionSource:UniProtKB-KW
Biological Process negative regulation of angiogenesisSource:UniProtKB1 Publication
Biological Process positive regulation of synapse assemblySource:Ensembl
Biological Process negative regulation of angiogenesisSource:UniProtKB1 Publication
Biological Process positive regulation of synapse assemblySource:Ensembl
Cellular Location
basement membrane
collagen-containing extracellular matrix
extracellular region
platelet alpha granule
collagen-containing extracellular matrix
extracellular region
platelet alpha granule
Involvement in disease
Intervertebral disc disease (IDD):
A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.
A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.
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Anti-THBS2 antibodies
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Target: THBS2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-2948
Application*: E
Target: THBS2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2947
Application*: WB
Target: THBS2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-2946
Application*: WB
Target: THBS2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2945
Application*: E
Target: THBS2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2944
Application*: WB, IF
Target: THBS2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-2943
Application*: WB
Target: THBS2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-2942
Application*: EC
Target: THBS2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-2941
Application*: WB
Target: Thbs2
Sensitivity: 0.125 ng/mL
Detection Range: 0.2-60 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: THBS2
Sensitivity: 0.23 ng/mL
Detection Range: 0.5-200 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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