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THEMIS2

THEMIS2 (Thymocyte Selection Associated Family Member 2) is a Protein Coding gene. Diseases associated with THEMIS2 include Endometrial Adenocarcinoma. An important paralog of this gene is THEMIS.

Full Name

THEMIS2 Gene(Protein Coding)

Thymocyte Selection Associated Family Member 2

Function

May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716).
Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity).

Biological Process

Biological Process cell adhesionSource:ProtInc1 Publication
Biological Process inflammatory responseSource:UniProtKB-KW
Biological Process regulation of B cell activationSource:UniProtKB
Biological Process T cell receptor signaling pathwaySource:GO_Central1 Publication

Cellular Location

Nucleus
Cytoplasm

PTM

Phosphorylation at Tyr-632 is induced by LPS. Phosphorylated by Src kinases (Lck or Fyn) following BCR engagement.

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Anti-THEMIS2 antibodies

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Mouse Anti-THEMIS2 Recombinant Antibody (1C3) (CBMAB-A0953-LY)

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Target: THEMIS2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C3

Application*: SE, E

Mouse Anti-THEMIS2 Recombinant Antibody (CBLC270-LY) (CBMAB-C12496-LY)

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Target: THEMIS2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLC270-LY

Application*: E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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