THEMIS2

THEMIS2 (Thymocyte Selection Associated Family Member 2) is a Protein Coding gene. Diseases associated with THEMIS2 include Endometrial Adenocarcinoma. An important paralog of this gene is THEMIS.

Full Name

THEMIS2 Gene(Protein Coding)

Thymocyte Selection Associated Family Member 2

Function

May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716).
Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity).

Biological Process

Biological Process cell adhesionSource:ProtInc1 Publication
Biological Process inflammatory responseSource:UniProtKB-KW
Biological Process regulation of B cell activationSource:UniProtKB
Biological Process T cell receptor signaling pathwaySource:GO_Central1 Publication

Cellular Location

Nucleus
Cytoplasm

PTM

Phosphorylation at Tyr-632 is induced by LPS. Phosphorylated by Src kinases (Lck or Fyn) following BCR engagement.

Anti-THEMIS2 antibodies

Mouse Anti-THEMIS2 Recombinant Antibody (CBLC270-LY) (CBMAB-C12496-LY)

Datasheet

SDS

Target: THEMIS2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLC270-LY

Application*: E

Mouse Anti-THEMIS2 Recombinant Antibody (1C3) (CBMAB-A0953-LY)

Datasheet

SDS

Target: THEMIS2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C3

Application*: SE, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)