THOC3

TEX1 is part of the TREX (transcription/export) complex, which includes THO2 (MIM 300395), HPR1 (MIM 606930), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM
Full Name
THO complex 3
Function
Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Biological Process
Biological Process mRNA export from nucleusSource:UniProtKB1 Publication
Biological Process mRNA processingSource:UniProtKB-KW
Biological Process RNA splicingSource:UniProtKB-KW
Biological Process viral mRNA export from host cell nucleusSource:UniProtKB1 Publication
Cellular Location
Nucleus
Nucleus speckle
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Anti-THOC3 antibodies

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Mouse Anti-THOC3 Recombinant Antibody (CBYJT-2997) (CBMAB-T2246-YJ)

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Target: THOC3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-2997
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-THOC3 Recombinant Antibody (CBYJT-2996) (CBMAB-T2245-YJ)

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Target: THOC3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-2996
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-THOC3 Recombinant Antibody (CBYJT-2995) (CBMAB-T2244-YJ)

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Target: THOC3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2995
Application*: WB, SE, E
Datasheet SDS

Mouse Anti-THOC3 Recombinant Antibody (CBYJT-2994) (CBMAB-T2243-YJ)

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Target: THOC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2994
Application*: WB, IH
Datasheet SDS

Mouse Anti-THOC3 Recombinant Antibody (CBYJT-2993) (CBMAB-T2242-YJ)

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Target: THOC3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2993
Application*: E, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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