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THOC3

TEX1 is part of the TREX (transcription/export) complex, which includes THO2 (MIM 300395), HPR1 (MIM 606930), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM

Full Name

THO complex 3

Function

Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Biological Process

Biological Process mRNA export from nucleusSource:UniProtKB1 Publication
Biological Process mRNA processingSource:UniProtKB-KW
Biological Process RNA splicingSource:UniProtKB-KW
Biological Process viral mRNA export from host cell nucleusSource:UniProtKB1 Publication

Cellular Location

Nucleus
Nucleus speckle

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Anti-THOC3 antibodies

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Mouse Anti-THOC3 Recombinant Antibody (CBYJT-2997) (CBMAB-T2246-YJ)

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Target: THOC3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Clone: CBYJT-2997

Application*: WB, IP, IF, E

Mouse Anti-THOC3 Recombinant Antibody (CBYJT-2996) (CBMAB-T2245-YJ)

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Target: THOC3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Clone: CBYJT-2996

Application*: WB, IP, IF, E

Mouse Anti-THOC3 Recombinant Antibody (CBYJT-2995) (CBMAB-T2244-YJ)

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Target: THOC3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYJT-2995

Application*: WB, SE, E

Mouse Anti-THOC3 Recombinant Antibody (CBYJT-2994) (CBMAB-T2243-YJ)

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Target: THOC3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2994

Application*: WB, IH

Mouse Anti-THOC3 Recombinant Antibody (CBYJT-2993) (CBMAB-T2242-YJ)

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Target: THOC3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYJT-2993

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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