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Mouse Anti-THOC3 Recombinant Antibody (CBYJT-2993) (CBMAB-T2242-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to THOC3 (THO Complex 3). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all THOC3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2993
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa252-352 from human THOC3 (NP_115737) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 252-352

Target

Full Name
THO complex 3
Introduction
THOC3 is a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development.
Entrez Gene ID
84321
UniProt ID
Q96J01
Alternative Names
THO Complex 3; TEX1 Homolog; HTREX45; THO3; THO Complex Subunit 3
Function
Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Biological Process
Biological Process mRNA export from nucleusSource:UniProtKB1 Publication
Biological Process mRNA processingSource:UniProtKB-KW
Biological Process RNA splicingSource:UniProtKB-KW
Biological Process viral mRNA export from host cell nucleusSource:UniProtKB1 Publication
Cellular Location
Nucleus
Nucleus speckle
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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