TIMM13

TIMM13 is a member of the evolutionarily conserved TIMM (translocase of inner mitochondrial membrane) family of proteins that play a role as chaperones in the import of proteins from the cytoplasm into the mitochondrial inner membrane. Proteins of this family function in collecting substrate proteins from the translocase of the outer mitochondrial membrane (TOM) complex and delivering them to either the sorting and assembly machinery in the outer mitochondrial membrane (SAM) complex or the TIMM22 complex in the inner mitochondrial membrane. TIMM13 and the translocase of mitochondrial inner membrane 8a protein form a 70 kDa complex in the intermembrane space.

Translocase Of Inner Mitochondrial Membrane 13

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins.

Biological Process protein insertion into mitochondrial inner membraneSource:GO_Central1 Publication
Biological Process protein targeting to mitochondrionSource:ProtInc1 Publication
Biological Process sensory perception of soundSource:ProtInc1 Publication

Mitochondrion inner membrane