TKFC

This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2017]

Full Name

TKFC Gene(Protein Coding) Triokinase And FMN Cyclase

Function

Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090).

Biological Process

Carbohydrate phosphorylation Source: UniProtKB
Cellular carbohydrate metabolic process Source: UniProtKB
Fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate Source: Reactome
Glycerol catabolic process Source: GO_Central
Innate immune response Source: Reactome
Negative regulation of MDA-5 signaling pathway Source: UniProtKB
Regulation of innate immune response Source: UniProtKB

Cellular Location

Cytosol; Extracellular exosome; Nucleus

Involvement in disease

Triokinase and FMN cyclase deficiency syndrome (TKFCD):
An autosomal recessive disease characterized by cataracts and developmental delay that may be associated with cerebellar hypoplasia. Additional features may include liver dysfunction, microcytic anemia, and fatal cardiomyopathy with lactic acidosis following a febrile illness.