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Mouse Anti-TKFC Recombinant Antibody (CBYJT-3271) (CBMAB-T2556-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3271
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TKFC Gene(Protein Coding) Triokinase And FMN Cyclase
Introduction
TKFC is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of TKFC phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4', 5'-phosphate (aka cyclin FMN) from FAD.
Entrez Gene ID
26007
UniProt ID
Q3LXA3
Alternative Names
Triokinase And FMN Cyclase; Bifunctional ATP-Dependent Dihydroxyacetone Kinase/FAD-AMP Lyase (Cyclizing); Triokinase/FMN Cyclase; DAK; Dihydroxyacetone Kinase 2 Homolog (S. Cerevisiae); Testis Tissue Sperm-Binding Protein Li 84P; Dihydroxyacetone Kinase 2 Homolog (Yeast); ATP-Dependent Dihydroxyacetone Kinase; Dihydroxyacetone Kinase 2 Homolog
Function
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090).
Biological Process
Carbohydrate phosphorylation Source: UniProtKB
Cellular carbohydrate metabolic process Source: UniProtKB
Fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate Source: Reactome
Glycerol catabolic process Source: GO_Central
Innate immune response Source: Reactome
Negative regulation of MDA-5 signaling pathway Source: UniProtKB
Regulation of innate immune response Source: UniProtKB
Cellular Location
Cytosol; Extracellular exosome; Nucleus
Involvement in disease
Triokinase and FMN cyclase deficiency syndrome (TKFCD):
An autosomal recessive disease characterized by cataracts and developmental delay that may be associated with cerebellar hypoplasia. Additional features may include liver dysfunction, microcytic anemia, and fatal cardiomyopathy with lactic acidosis following a febrile illness.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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