Mouse Anti-TKFC Recombinant Antibody (CBYJT-3271) (CBMAB-T2556-YJ)

Name: Mouse Anti-TKFC Recombinant Antibody (CBYJT-3271)
SKU: CBMAB-T2556-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3271

Application

ELISA

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TKFC Gene(Protein Coding) Triokinase And FMN Cyclase

Introduction

TKFC is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of TKFC phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4', 5'-phosphate (aka cyclin FMN) from FAD.

Entrez Gene ID

26007

UniProt ID

Q3LXA3

Alternative Names

Triokinase And FMN Cyclase; Bifunctional ATP-Dependent Dihydroxyacetone Kinase/FAD-AMP Lyase (Cyclizing); Triokinase/FMN Cyclase; DAK; Dihydroxyacetone Kinase 2 Homolog (S. Cerevisiae); Testis Tissue Sperm-Binding Protein Li 84P; Dihydroxyacetone Kinase 2 Homolog (Yeast); ATP-Dependent Dihydroxyacetone Kinase; Dihydroxyacetone Kinase 2 Homolog

Function

Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090).

Biological Process

Carbohydrate phosphorylation Source: UniProtKB
Cellular carbohydrate metabolic process Source: UniProtKB
Fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate Source: Reactome
Glycerol catabolic process Source: GO_Central
Innate immune response Source: Reactome
Negative regulation of MDA-5 signaling pathway Source: UniProtKB
Regulation of innate immune response Source: UniProtKB

Cellular Location

Cytosol; Extracellular exosome; Nucleus

Involvement in disease

Triokinase and FMN cyclase deficiency syndrome (TKFCD):
An autosomal recessive disease characterized by cataracts and developmental delay that may be associated with cerebellar hypoplasia. Additional features may include liver dysfunction, microcytic anemia, and fatal cardiomyopathy with lactic acidosis following a febrile illness.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rabbit Anti-TKFC Recombinant Antibody (EG921) (CAT#: CBMAB-EN1092-LY)

Isotype control

For research use only. Not intended for any clinical use.

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