TNR

Tenascin-R (TNR) is an extracellular matix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion; MIM 187380), TNX (TNXB; MIM 600985), and TNR (Erickson, 1993 [PubMed 7694605]). The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM

tenascin R (restrictin, janusin)

Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).

Biological Process associative learning Source:Ensembl
Biological Process axon extension involved in regeneration Source:Ensembl
Biological Process axon guidance Source:ProtInc1 Publication
Biological Process cell adhesion Source:GO_Central1 Publication
Biological Process extracellular matrix organization Source:Ensembl
Biological Process locomotory exploration behavior Source:Ensembl
Biological Process long-term synaptic potentiation Source:Ensembl
Biological Process negative regulation of axon extension involved in regeneration Source:Ensembl
Biological Process negative regulation of cell-cell adhesion Source:Ensembl
Biological Process negative regulation of synaptic transmission Source:Ensembl
Biological Process neuromuscular process controlling balance Source:Ensembl
Biological Process neuron cell-cell adhesion Source:Ensembl
Biological Process positive regulation of synaptic transmission, glutamatergic Source:Ensembl
Biological Process positive regulation of transmission of nerve impulse Source:Ensembl
Biological Process regulation of cell migration Source:Ensembl
Biological Process synapse organization Source:Ensembl
Biological Process synaptic transmission, glutamatergic Source:Ensembl
Biological Process telencephalon cell migration Source:Ensembl

Secreted, extracellular space, extracellular matrix

Neurodevelopmental disorder, non-progressive, with spasticity and transient opisthotonus (NEDSTO):
An autosomal recessive disorder characterized by delayed motor milestones, delayed walking, speech delay, axial hypotonia, and peripheral spasticity apparent from infancy or early childhood. Affected individuals often show transient opisthotonic posturing in infancy, and later show abnormal involuntary movements. Variably impaired intellectual development, and brain myelination defects are present in some patients.

Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity).
O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan.