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Mouse Anti-TNR Recombinant Antibody (CBYJT-4124) (CBMAB-T3565-YJ)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBYJT-4124
Application
S-ELISA, ELISA
Immunogen
TNR (NP_003276, 411 a.a. ~ 519 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 411-519
More Infomation

Target

Full Name
tenascin R (restrictin, janusin)
Introduction
TNR is a member of the tenascin family of extracellular matrix glycoproteins. TNR is restricted to the central nervous system. The protein may function in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets.
Entrez Gene ID
7143
UniProt ID
Q92752
Alternative Names
Tenascin R; Restrictin; Janusin; TN-R; Tenascin-R
Function
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).
Biological Process
Biological Process associative learning Source:Ensembl
Biological Process axon extension involved in regeneration Source:Ensembl
Biological Process axon guidance Source:ProtInc1 Publication
Biological Process cell adhesion Source:GO_Central1 Publication
Biological Process extracellular matrix organization Source:Ensembl
Biological Process locomotory exploration behavior Source:Ensembl
Biological Process long-term synaptic potentiation Source:Ensembl
Biological Process negative regulation of axon extension involved in regeneration Source:Ensembl
Biological Process negative regulation of cell-cell adhesion Source:Ensembl
Biological Process negative regulation of synaptic transmission Source:Ensembl
Biological Process neuromuscular process controlling balance Source:Ensembl
Biological Process neuron cell-cell adhesion Source:Ensembl
Biological Process positive regulation of synaptic transmission, glutamatergic Source:Ensembl
Biological Process positive regulation of transmission of nerve impulse Source:Ensembl
Biological Process regulation of cell migration Source:Ensembl
Biological Process synapse organization Source:Ensembl
Biological Process synaptic transmission, glutamatergic Source:Ensembl
Biological Process telencephalon cell migration Source:Ensembl
Cellular Location
Secreted, extracellular space, extracellular matrix
Involvement in disease
Neurodevelopmental disorder, non-progressive, with spasticity and transient opisthotonus (NEDSTO):
An autosomal recessive disorder characterized by delayed motor milestones, delayed walking, speech delay, axial hypotonia, and peripheral spasticity apparent from infancy or early childhood. Affected individuals often show transient opisthotonic posturing in infancy, and later show abnormal involuntary movements. Variably impaired intellectual development, and brain myelination defects are present in some patients.
PTM
Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity).
O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-TNR Recombinant Antibody (CBYJT-4123) (CAT#: CBMAB-T3564-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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