TOB1

TOB1 is a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. TOB1 may play a role as a tumor suppressor.

Full Name

Transducer Of ERBB2, 1

Function

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473).
Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).

Biological Process

Biological Process negative regulation of BMP signaling pathway Source:Ensembl
Biological Process negative regulation of cell population proliferation Source:UniProtKB2 Publications
Biological Process negative regulation of nuclear-transcribed mRNA poly(A) tail shortening Source:UniProtKB1 Publication
Biological Process negative regulation of osteoblast differentiation Source:Ensembl
Biological Process negative regulation of translation Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source:UniProtKB1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of SMAD protein signal transduction Source:Ensembl

Cellular Location

Cytoplasm
Nucleus
Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic.

PTM

Phosphorylated on Ser and Thr residues.