Mouse Anti-TOB1 Recombinant Antibody (CBYJT-4136) (CBMAB-T3583-YJ)

Name: Mouse Anti-TOB1 Recombinant Antibody (CBYJT-4136)
SKU: CBMAB-T3583-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4136

Application

IHC-P, WB

Immunogen

Recombinant human TOB

Specificity

Human, Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Preservative

15 mM Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Transducer Of ERBB2, 1

Introduction

TOB1 is a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. TOB1 may play a role as a tumor suppressor.

Entrez Gene ID

Human	10140
Mouse	22057

UniProt ID

Human	P50616
Mouse	Q61471

Alternative Names

Transducer Of ERBB2, 1; Transducer Of ErbB-2 1; TROB1; TOB; Proliferation-Inducing Gene 49; Protein Tob1

Function

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473).
Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).

Biological Process

Biological Process negative regulation of BMP signaling pathway Source:Ensembl
Biological Process negative regulation of cell population proliferation Source:UniProtKB2 Publications
Biological Process negative regulation of nuclear-transcribed mRNA poly(A) tail shortening Source:UniProtKB1 Publication
Biological Process negative regulation of osteoblast differentiation Source:Ensembl
Biological Process negative regulation of translation Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source:UniProtKB1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of SMAD protein signal transduction Source:Ensembl

Cellular Location

Cytoplasm
Nucleus
Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic.

PTM

Phosphorylated on Ser and Thr residues.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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