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Mouse Anti-TOB1 Recombinant Antibody (CBYJT-4136) (CBMAB-T3583-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TOB1 (Transducer Of ERBB2, 1). The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all TOB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYJT-4136
Antibody Isotype
IgG2a
Application
IHC-P, WB

Basic Information

Immunogen
Recombinant human TOB
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Preservative
15 mM Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transducer Of ERBB2, 1
Introduction
TOB1 is a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. TOB1 may play a role as a tumor suppressor.
Entrez Gene ID
Human10140
Mouse22057
UniProt ID
HumanP50616
MouseQ61471
Alternative Names
Transducer Of ERBB2, 1; Transducer Of ErbB-2 1; TROB1; TOB; Proliferation-Inducing Gene 49; Protein Tob1
Function
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473).
Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).
Biological Process
Biological Process negative regulation of BMP signaling pathway Source:Ensembl
Biological Process negative regulation of cell population proliferation Source:UniProtKB2 Publications
Biological Process negative regulation of nuclear-transcribed mRNA poly(A) tail shortening Source:UniProtKB1 Publication
Biological Process negative regulation of osteoblast differentiation Source:Ensembl
Biological Process negative regulation of translation Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source:UniProtKB1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of SMAD protein signal transduction Source:Ensembl
Cellular Location
Cytoplasm
Nucleus
Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic.
PTM
Phosphorylated on Ser and Thr residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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