TRIM40

TRIM40 is a member of the tripartite motif (TRIM) protein family. TRIM40 may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract.

Full Name

Tripartite Motif Containing 40

Function

E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response (PubMed:21474709, PubMed:29117565).
Mediates inhibition of the RLR signaling pathway by ubiquitinating DDX58 and IFIH1 receptors, leading to their proteasomal degradation (PubMed:21474709).
Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation (PubMed:21474709).

Biological Process

Biological Process innate immune response Source:GO_Central1 Publication
Biological Process negative regulation of cell growth Source:Ensembl
Biological Process negative regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process negative regulation of NIK/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process negative regulation of protein catabolic process Source:UniProtKB1 Publication
Biological Process negative regulation of protein localization to nucleus Source:UniProtKB1 Publication
Biological Process protein neddylation Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication

Cellular Location

cytoplasm
IkappaB kinase complex