Mouse Anti-TRIM40 Recombinant Antibody (CBYJT-4779) (CBMAB-T4320-YJ)

Name: Mouse Anti-TRIM40 Recombinant Antibody (CBYJT-4779)
SKU: CBMAB-T4320-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-4779

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa102-200 (NP_055586) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 102-200

More Infomation

Target

Full Name

Tripartite Motif Containing 40

Introduction

TRIM40 is a member of the tripartite motif (TRIM) protein family. TRIM40 may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract.

Entrez Gene ID

135644

UniProt ID

Q6P9F5

Alternative Names

Tripartite Motif Containing 40; Probable E3 NEDD8-Protein Ligase; RING Finger Protein 35; RNF35; Tripartite Motif-Containing Protein 40; Tripartite Motif-Containing 40; Ring Finger RNF35

Function

E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response (PubMed:21474709, PubMed:29117565).
Mediates inhibition of the RLR signaling pathway by ubiquitinating DDX58 and IFIH1 receptors, leading to their proteasomal degradation (PubMed:21474709).
Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation (PubMed:21474709).

Biological Process

Biological Process innate immune response Source:GO_Central1 Publication
Biological Process negative regulation of cell growth Source:Ensembl
Biological Process negative regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process negative regulation of NIK/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process negative regulation of protein catabolic process Source:UniProtKB1 Publication
Biological Process negative regulation of protein localization to nucleus Source:UniProtKB1 Publication
Biological Process protein neddylation Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication

Cellular Location

cytoplasm
IkappaB kinase complex

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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