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Mouse Anti-TRIM40 Recombinant Antibody (CBYJT-4779) (CBMAB-T4320-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM40 (Tripartite Motif Containing 40). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TRIM40 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4779
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa102-200 (NP_055586) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 102-200

Target

Full Name
Tripartite Motif Containing 40
Introduction
TRIM40 is a member of the tripartite motif (TRIM) protein family. TRIM40 may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract.
Entrez Gene ID
UniProt ID
Alternative Names
Tripartite Motif Containing 40; Probable E3 NEDD8-Protein Ligase; RING Finger Protein 35; RNF35; Tripartite Motif-Containing Protein 40; Tripartite Motif-Containing 40; Ring Finger RNF35
Function
E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response (PubMed:21474709, PubMed:29117565).
Mediates inhibition of the RLR signaling pathway by ubiquitinating DDX58 and IFIH1 receptors, leading to their proteasomal degradation (PubMed:21474709).
Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation (PubMed:21474709).
Biological Process
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process negative regulation of cell growth Source:Ensembl
Biological Process negative regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process negative regulation of NIK/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process negative regulation of protein catabolic process Source:UniProtKB1 Publication
Biological Process negative regulation of protein localization to nucleus Source:UniProtKB1 Publication
Biological Process protein neddylation Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Cellular Location
cytoplasm
IkappaB kinase complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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