TRIP10

TRIP10 (Thyroid Hormone Receptor Interactor 10) is a Protein Coding gene. Diseases associated with TRIP10 include Wiskott-Aldrich Syndrome. Among its related pathways are Vesicle-mediated transport and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include identical protein binding and lipid binding. An important paralog of this gene is FNBP1L.

Full Name

thyroid hormone receptor interactor 10

Function

Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity).
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

Biological Process

Biological Process actin cytoskeleton organization Source:UniProtKB1 Publication
Biological Process cell communication Source:UniProtKB1 Publication
Biological Process endocytosis Source:UniProtKB-KW
Biological Process signal transduction Source:ProtInc1 Publication

Cellular Location

Cytoplasm, cytoskeleton
Cytoplasm, cell cortex
Lysosome
Golgi apparatus
Cell membrane
Cell projection, phagocytic cup
Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity).
Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.
Isoform 5
Cytoplasm, perinuclear region

PTM

Tyrosine phosphorylated. Also phosphorylated by PKA.