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Mouse Anti-TRIP10 Recombinant Antibody (CBYJT-4850) (CBMAB-T4394-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIP10 (Thyroid Hormone Receptor Interactor 10). The antibody can be used for immunoassay techniques, such as ELISA, IF, IP, WB.
See all TRIP10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4850
Antibody Isotype
IgG2b, κ
Application
ELISA, IF, IP, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa231-329 from TRIP10 (NP_004231) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 231-329

Target

Full Name
thyroid hormone receptor interactor 10
Introduction
TRIP10 (Thyroid Hormone Receptor Interactor 10) is a Protein Coding gene. Diseases related to TRIP10 include Wiskott-Aldrich Syndrome. Among its related pathways are Vesicle-mediated transport and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to TRIP10 include identical protein binding and lipid binding. An important paralog of TRIP10 is FNBP1L.
Entrez Gene ID
9322
UniProt ID
Q15642
Alternative Names
Thyroid Hormone Receptor Interactor 10; Thyroid Receptor-Interacting Protein 10; TR-Interacting Protein 10; Salt Tolerant Protein; Salt Tolerator; Protein Felic; TRIP-10
Function
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity).
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
Biological Process
Biological Process actin cytoskeleton organization Source:UniProtKB1 Publication
Biological Process cell communication Source:UniProtKB1 Publication
Biological Process endocytosis Source:UniProtKB-KW
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, cell cortex
Lysosome
Golgi apparatus
Cell membrane
Cell projection, phagocytic cup
Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity).
Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.
Isoform 5
Cytoplasm, perinuclear region
PTM
Tyrosine phosphorylated. Also phosphorylated by PKA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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