Mouse Anti-TRIP10 Recombinant Antibody (CBYJT-4850) (CBMAB-T4394-YJ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
Biological Process cell communication Source:UniProtKB1 Publication
Biological Process endocytosis Source:UniProtKB-KW
Biological Process signal transduction Source:ProtInc1 Publication
Cytoplasm, cell cortex
Lysosome
Golgi apparatus
Cell membrane
Cell projection, phagocytic cup
Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity).
Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.
Isoform 5
Cytoplasm, perinuclear region
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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