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UBE2J1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq]
Full Name
UBE2J1
Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress (PubMed:28321712).
Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis (PubMed:24020373).
Acts also as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26 (PubMed:33472082).
(Microbial infection) Promotes Dengue virus RNA replication by negatively regulating IFN-beta signaling and mediating 'Lys-48'-linked ubiquitination on IRF3 (PubMed:30157886).
Biological Process
Biological Process negative regulation of retrograde protein transport, ER to cytosol Source:ParkinsonsUK-UCL1 Publication
Biological Process protein N-linked glycosylation via asparagine Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process regulation of macrophage cytokine production Source:Ensembl
Biological Process regulation of tumor necrosis factor production Source:Ensembl
Biological Process spermatid development Source:Ensembl
Biological Process ubiquitin-dependent ERAD pathway Source:UniProtKB1 Publication
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-282
Helical: 283-303
Lumenal: 304-318
PTM
Phosphorylated at Ser-184 in a cytosolic stress-dependent manner by MAP kinase p38 MAPKAPK2.
Phosphorylated UBE2J1 is rapidly ubiquitinated and subsequently degraded by the proteasome.

Anti-UBE2J1 antibodies

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Target: UBE2J1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12BA23
Application*: E, WB
Target: UBE2J1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12BA24
Application*: E, WB
Target: UBE2J1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12BA25
Application*: E, WB
Target: UBE2J1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: CBFYU-120
Application*: WB, IH, F
Target: UBE2J1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYU-121
Application*: E, WB
Target: UBE2J1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYU-122
Application*: WB, P, F
Target: UBE2J1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYU-123
Application*: F, P, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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