Human Recombinant UBE2J1 protein, GST Tag (V2LY-0526-LY7480)

Name: Human Recombinant UBE2J1 protein, GST Tag
SKU: V2LY-0526-LY7480
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant UBE2J1 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 70 kDa.

Molecule Mass

70 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

UBE2J1

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress (PubMed:28321712).
Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis (PubMed:24020373).
Acts also as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26 (PubMed:33472082).
(Microbial infection) Promotes Dengue virus RNA replication by negatively regulating IFN-beta signaling and mediating 'Lys-48'-linked ubiquitination on IRF3 (PubMed:30157886).

Biological Process

Biological Process negative regulation of retrograde protein transport, ER to cytosol Source:ParkinsonsUK-UCL1 Publication
Biological Process protein N-linked glycosylation via asparagine Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process regulation of macrophage cytokine production Source:Ensembl
Biological Process regulation of tumor necrosis factor production Source:Ensembl
Biological Process spermatid development Source:Ensembl
Biological Process ubiquitin-dependent ERAD pathway Source:UniProtKB1 Publication

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 1-282
Helical: 283-303
Lumenal: 304-318

PTM

Phosphorylated at Ser-184 in a cytosolic stress-dependent manner by MAP kinase p38 MAPKAPK2.
Phosphorylated UBE2J1 is rapidly ubiquitinated and subsequently degraded by the proteasome.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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