USF1
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
Full Name
USF1
Function
Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
Biological Process
Biological Process carbon catabolite regulation of transcription Source:BHF-UCL1 Publication
Biological Process cellular response to insulin stimulus Source:BHF-UCL1 Publication
Biological Process glucose homeostasis Source:BHF-UCL1 Publication
Biological Process late viral transcription Source:BHF-UCL1 Publication
Biological Process lipid homeostasis Source:BHF-UCL
Biological Process negative regulation of fibrinolysis Source:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL2 Publications
Biological Process positive regulation of transcription from RNA polymerase II promoter by glucose Source:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process regulation of transcription from RNA polymerase II promoter by glucose Source:BHF-UCL1 Publication
Biological Process response to hypoxia Source:BHF-UCL1 Publication
Biological Process response to UV Source:BHF-UCL
Biological Process cellular response to insulin stimulus Source:BHF-UCL1 Publication
Biological Process glucose homeostasis Source:BHF-UCL1 Publication
Biological Process late viral transcription Source:BHF-UCL1 Publication
Biological Process lipid homeostasis Source:BHF-UCL
Biological Process negative regulation of fibrinolysis Source:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL2 Publications
Biological Process positive regulation of transcription from RNA polymerase II promoter by glucose Source:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process regulation of transcription from RNA polymerase II promoter by glucose Source:BHF-UCL1 Publication
Biological Process response to hypoxia Source:BHF-UCL1 Publication
Biological Process response to UV Source:BHF-UCL
Cellular Location
Nucleus
Involvement in disease
Hyperlipidemia, familial combined, 1 (FCHL1):
A disorder characterized by a variable pattern of elevated levels of serum total cholesterol, triglycerides or both. It is observed in a percentage of individuals with premature coronary heart disease.
A disorder characterized by a variable pattern of elevated levels of serum total cholesterol, triglycerides or both. It is observed in a percentage of individuals with premature coronary heart disease.
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Anti-USF1 antibodies
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Target: USF1
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: G-2
Application*: WB, IP, IF, E
Target: USF1
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: B-9
Application*: WB, IP, IF, E
Target: USF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3F6
Application*: E, WB
Target: USF1
Host: Mouse
Specificity: Human
Clone: 2A7
Application*: E, WB
Target: USF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1264CT170.274.14
Application*: WB
Target: USF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C10
Application*: IP, E, WB
Target: USF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B8
Application*: IP, M
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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